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发布于:2018-8-8 18:43:29  访问:62 次 回复:0 篇
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T al. Diagnostic Pathology (2015) ten:Page four ofof cancer cells by targeting DICER
Diagnostic Pathology (2015) ten:Page 4 ofof cancer cells by targeting DICER1 [35]. The involvement of miR-130b in CRC-related angiogenesis and EMT has been CI-994Protocol previously shown. In hypoxic conditions, miR-130b represses DDX6 top to improved activity of HIF1, a well-known VEGF inducer. In addition, deregulation of RET Kinase inhibitor 1 cost miR-218 was reported in a lot of types of tumors [25?0]. Down-regulation of it has been discovered in lung, prostate, cervical, colon, gastric, bladder cancer and hepatocellular carcinoma [25?9]. Moreover, decreased expression of miR-218 was related to a important worse survival of HCC individuals. Down regulation of miR-218 was found in osteosarcoma tissues [31]. Furthermore, it has been reported that miR-218 inhibited osteosarcoma cell migration and invasion by downregulating T-cell lymphoma invasion and metastasis 1 (TIAM1), matrix metalloproteinase2 (MMP2) and MMP9 [31]. Within the present study, the degree of miR-218 expression in osteosarcoma tissues was down-regulated in comparison with adjacent non-tumor tissues. We evaluated the clinical significance of miR-218 in osteosarcoma. Clinical correlation analysis showed that decreased expression of miR-218 was drastically related with advanced tumor stage, distant metastasis and size of tumor. These final results recommended that low degree of miR-218 is linked with poor clinicopathological traits. It has been reported that the low degree of miR-218 is connected with TNM stage, lymph node metastasis and histological differentiation in colon cancer. Additionally, individuals with low miR-218 expression had shorter survival in colon cancer [27]. Reduced degree of miR-218 has been found in individuals with large tumor size PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28914615 and advanced TNM tumor stage in hepatocellular carcinoma tissues [30]. Our findings recommended that that miR-218 might be a possible marker in osteosarcoma patients. A prior study indicated that LEF1 is usually a new direct target of miR-218, and miR-218 can lessen protein levels of LEF1 and MMP-9 in glioblastoma cells. They hypothesized that miR-218 can straight target LEF1, resulting in decreased synthesis of MMP-9. Additionally, they concluded that miR-218 is involved inside the invasive behavior of GBM cells and by targeting LEF1 and blocking the invasive axis, miR-218-LEF1-MMPs, it may be beneficial for developing potential clinical strategies [36]. Jin et al. [31] indicated that miR-218 can act as inhibitor of osteosarcoma cell migration and invasion by down-regulating TIAM1, MMP2 and MMP9 expression [18]. Nevertheless, further research are needed to clarify the role of miR-218 in osteosarcoma cell proliferation and apoptosis.Abbreviations OS: Osteosarcoma; 3-UTR: 3untranslated region; CT: Cycle threshold; UICC: Union for International Cancer Manage; WHO: Globe Overall health Organization; TNM: Tumor-nodemetastases; TIAM1: T-cell lymphoma invasion and metastasis1; MMP2: Matrix metalloproteinase2. Competing interests The authors declare that they have no competing interests. Authors‘ contributions AT, AJT, MJ, MSH, SKH and EY participated in sample collection and processing and coordination and helped to draft the manuscript and information analyses and manuscript preparation. MSH participated in design PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26778282 in the study and writing. The authors read and approved the final manuscript.TERET RConclusions In summary, our information indicated that higher miR-130b level and low amount of miR-218 are linked with poor clinicopathological qualities.T al.
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