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发布于:2019-1-16 15:45:32  访问:31 次 回复:0 篇
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Acteristics for example prognosis and aggressiveness, too as, molecular alterations
Type II endometrial tumors are* Correspondence: cychuang@mx.nthu.edu.tw 1 Department of Biomedical Banoxantrone (dihydrochloride) biological activity Engineering and Environmental Sciences, Vaborbactam site National Tsing Hua University, Hsinchu 30013, Taiwan Full list of author information is readily available in the end in the articleserous carcinoma which have been linked with older, non-obese, post-menopausal females, high-grade (undifferentiated), as well as with worst outcomes. Type I tumors are regularly characterized by the loss or altered expression of phosphatase and tensin homolog (PTEN). PTEN modulates cell survival and proliferation via its effects on downstream components, mostly phospholipid phosphatidylinositol (3, four, 5)triphosphate (PIP3) and protein kinase B (PKB, Akt). PTEN inactivation leads to a decrease of lipid and protein phosphatase activity and promotes cell cycle progression towards the G1/S phase [7]. Other genes are linked to abnormalities in Type I tumors including-catenin, K-ras and DNA-mismatch repair genes [7-10]. Sort II endometrial tumors are* Correspondence: cychuang@mx.nthu.edu.tw 1 Division of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan Full list of author facts is available in the end of your articleserous carcinoma that have been associated with older, non-obese, post-menopausal ladies, high-grade (undifferentiated), and also with worst outcomes. It has been suggested that the molecular-genetic alterations could possibly be accountable for the distinct morphology and biologic behavior of the various subtypes of human ECs [4]. For instance, low-grade or early-stage Sort I tumors may perhaps progress to high-grade or late-stage; nonetheless Form I and II cancers appear to be separate entities in most cases, and various molecular abnormalities would outcome PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/29069523 in exceptional cellular functions and distinctive tumor morphology [5]. For that reason, it is crucial to discover with more accuracy the putative molecular signatures of ECs, which should let for enhanced detection and monitoring of endometrial tumorigenesis, since such understanding may very well be effective for early diagnostic, enhanced prognostic, and more effective therapeutic strategies.?2014 Chou et al.; licensee BioMed Central Ltd. That is an Open Access post distributed beneath the terms on the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original operate is correctly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies for the data produced available in this short article, unless otherwise stated.Chou et al. BMC Genomics 2014, 15:300 http://www.biomedcentral.com/1471-2164/15/Page two ofECs are PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28914615 characterized by many different genetic alterations and considerable gene expression modifications. More than the last decade, many studies have identified aberrant gene expression of various important genes in ECs, using the mutation frequency varying according to the histological classification [6]. Type I tumors are regularly characterized by the loss or altered expression of phosphatase and tensin homolog (PTEN). PTEN modulates cell survival and proliferation via its effects on downstream elements, mostly phospholipid phosphatidylinositol (3, four, five)triphosphate (PIP3) and protein kinase B (PKB, Akt). PTEN inactivation results in a lower of lipid and protein phosphatase activity and promotes cell cycle progression to the G1/S phase [7].
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