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发布于:2018-6-11 08:34:29  访问:18 次 回复:0 篇
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E activity improved a lot of fold (Figure five and six). Similar final results had been obtained
Pretreatment with aqueous extract significantlyEffects of CCl4 and CCl4 plus aqueous extract of Podophyllum hexandrum remedies on kidney and lung tissue SOD activity is CPI-203 supplier presented in Figure 7. BMC Complementary and Option Medicine 2011, 11:17 http://www.biomedcentral.com/1472-6882/11/Page six ofnmol NADPH oxidised/min/mg of proteinnmol NADPH oxidised/min/mg of protein20 18 16 14 12 ten eight six 4 2Co nt ro lg ro up gr ou p gr ou p ex tra ct ex tra ct ex tra ct70#50 40 30####@ @#@ #@10Co nt ro lg ro upgr ou pgr ou pex tra ctex tra ctCC lCC lEE20 m g/ kg30 m g/ kg20 m g/ kg50 m g/ kgVi ta m inFigure 4 Represents the dose dependent PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25852654 effect of aqueous extract of Podophyllum hexandrum on glutathione peroxidase activity against CCl4 induced toxicity in lung tissue homogenate. ; p < 0.001, as compared with normal control group, #; p < 0.001 as compared with CCl4 group, @; p < 0.001 as compared with V.E. The data were presented as means ?SD for six animals in each observation and evaluated by one-way ANOVA followed by Bonferroni t - test to detect inter group differences. Differences were considered to be statistically significant if p < 0.05.Figure 5 Represents the effect of aqueous extract of Podophyllum hexandrum on the glutathione reductase activity in kidney tissue. ; p < 0.001, as compared with normal control group, #; p < 0.001 as compared with CCl4 group, @; p < 0.001 as compared with V.E. The data were presented as means ?SD for six animals in each observation and evaluated by one-way ANOVA followed by Bonferroni t - test to detect inter group differences. Differences were considered to be statistically significant if p < 0.05.in CCl4 treated group. Administration of extract proved significantly better in restoring the altered activity of antioxidant enzyme like SOD, and increased the activity in a dose dependent manner in both organs. Similar results were observed in vitamin E treated group.Effect on GSH levelCCl 4 administration markedly decreased the levels of reduced glutathione PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/19451400 in both the kidney (control = 54.73 microgram/mg protein) and lung tissue (manage = 31.93 microgram/mg protein) to 9.62 (CCl4 group kidney) and six.53 (CCl4 group lung) CUDC-427 site demonstrating oxidative strain. Pretreatment with the aqueous extract of Podophyllum hexandrum considerably ameliorated CCl 4 -induced depletion of GSH in each lung and kidney inside a dose dependent manner (Figure 8 and 9).Effect on GST activitycontrol group (38.28 nmoles). Pretreatment with the aqueous extract for 15 days prior to CCl4 intoxication enhanced that activity substantially within a dose dependent manner. Within the lung homogenate GST activity of CCl4 treated group (5.22 nmoles) was decrease compared to that inside the normal group (9.11 nmoles), when the GST activity was identified to become elevated inside the lung tissue homogenate of rats treated with aqueous extract in the concentration of 20 and 30 mg/kg bw for 15 days before CCl four treatment. GST activity in vitamin E and 50 mg/kg bw plant extract pretreated group was close for the regular level in lung tissue.GST activity as measured in the lung an.E activity enhanced lots of fold (Figure five and 6).
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